肺动脉高血压中的日常体力活动:使用加速计的多中心纵向试验的见解.
Jasleen Minhas1, Haochang Shou2, Nadine Al-Naamani1
1Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
加速度计数据显示,肺动脉高血压 (PAH) 患者的日常身体活动与疾病严重程度相关,并预测临床恶化. 这些见解提供了一个以患者为中心的观点,超越了传统的测试.
科学领域:
- 心脏病学 心脏病学
- 肺部医学 肺部医学
- 生物医学工程 生物医学工程
背景情况:
- 肺动脉高血压 (PAH) 是一种严重的疾病,死亡率高.
- 传统的评估,如6分钟步行距离 (6MWD),可能不能完全代表PAH患者的日常活动.
- 需要对现实世界的身体活动进行客观测量,以更好地评估患者.
研究的目的:
- 为了确定PAH患者的加速仪测量每日体力活动是否反映了疾病严重程度,功能状态和长期结果.
- 探索身体活动水平与各种临床和患者报告结果之间的关系.
主要方法:
- 在PHANTOM试验中,PAH患者在12个月的4次访问中佩戴加速度计7天.
- 统计模型分析了日常活动与人口,临床和环境因素之间的关联.
- 评估了包括6MWD,生活质量 (HRQoL),骨矿物密度 (BMD) 和临床恶化时间在内的临床结果.
主要成果:
- 八十四名PAH患者被纳入;设备粘附率很高.
- 随着时间的推移,身体活动下降,并且在患有晚期疾病 (世卫组织功能类别III) 和较差VR功能的患者中较低.
- 较低的日常活动与更糟糕的HRQoL相关,较低的6MWD,减少的BMD,以及临床恶化的风险增加.
结论:
- 加速度计衍生体力活动是PAH疾病严重程度的有效指标.
- 每日活动指标与HRQoL,BMD相关,并预测临床恶化.
- 可穿戴传感器数据为传统的PAH评估提供了一个动态的,以患者为中心的补充.
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