与奥尔梅沙坦相关的状肠病症呈现为严重的腹
Silvia Suardi1, Marco Vicardi2, Carlotta Spillere2
1Department of Medicine, Unit of Internal Medicine B, University of Verona School of Medicine, Azienda Ospedaliera Universitaria Integrata Verona, Policlinico "G.B. Rossi", University of Verona, Verona, Veneto, Italy silvia.suardi@aovr.veneto.it.
BMJ case reports
|February 5, 2026
概括
奥尔梅沙坦药物可能会引起类似的肠病,导致严重的腹和急性损伤. 停止使用奥尔梅沙坦可以缓解症状,强调需要考虑药物诱导的肠道病变原因.
科学领域:
- 胃肠病学 胃肠病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床药理学 临床药理学
背景情况:
- 严重的水性腹和急性损伤 (AKI) 可能出现复杂的病因.
- 包括药物副作用在内的阳性病因在差异诊断中至关重要.
- 奥尔梅沙坦是一种广泛使用的抗高血压药物,已知有胃肠道不良影响.
研究的目的:
- 报告一个患者出现严重的水性腹和AKI的病例.
- 为了调查olmesartan使用和Spru-like enteropathy的发展之间的潜在联系.
- 强调在患有无法解释的胃肠道和脏症状的患者中考虑药物诱导肠道病变的重要性.
主要方法:
- 对病人的病史,临床表现和实验室调查进行全面的审查.
- 内镜检查 (胃镜检查) 使用十二指肠活检.
- 在停止使用奥尔梅沙坦后对临床反应的评估.
主要成果:
- 患者在恢复olmesartan后经历了反复出现的水性腹和AKI.
- 胃镜检查显示了严重的状缩和十二指肠炎症,但乳清学检测的乳清性疾病是负面的.
- 停用奥尔梅沙坦导致显著的临床改善,在没有改变饮食的情况下解决了腹和功能障碍.
结论:
- 奥尔梅沙坦可以诱导一种类似于的肠病,模仿乳病,并呈现出严重的胃肠道和脏并发症.
- 早期识别和停止使用侵权剂 (奥尔梅沙坦) 对于患者的康复至关重要.
- 这一案例强调了在重症肠道病变的差异诊断中需要包括阳性原因,特别是药物副作用.
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