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Updated: Feb 7, 2026

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通过RNAPII绕过阻断病变,揭示了由DNA损伤引起的新型压力

Carolina P Bañuelos1,2, Lucas D Caeiro1,2, Pradeepkumar R Cingaram1

  • 1Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA.

Genes & development
|February 5, 2026
PubMed
概括

乙转移酶p300调节了RNA聚合酶II (RNAPII) 从DNA损伤部位的去除. 损失p300允许RNAPII绕过病变,导致细胞内膜网膜应激,并使抗化疗的瘤重新敏感.

关键词:
造成的DNA损伤是DNA损伤.EP300 EP300 在线播放紫外线辐射 紫外线辐射化学疗法耐药的瘤化合物是一种化合物.转录合核酸切除修复的修复翻译压力 翻译压力

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