对长轴视野PET/CT深度学习对应注册框架的验证,在各种标志物中使用低辐射暴露协议
Zekai Li1, Laura Providência2, Philipp Mohr2
1Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; z.l.li@umcg.nl.
概括
一个深度学习框架准确地调整PET/CT扫描使用低剂量PET和超低剂量CT (ULD-CT) 在长轴视野 (LAFOV) 系统. 这种联合注册方法在各种标记物和减少辐射暴露协议中是稳健的.
科学领域:
- 医疗成像医学成像
- 放射化学 放射化学是指辐射化学.
- 人工智能的人工智能
背景情况:
- 长轴视野 (LAFOV) PET/CT系统提高全身成像灵敏度和覆盖范围.
- PET/CT 错位可能会导致人工物和量化错误,特别是在减少扫描时间和剂量的情况下.
- 超低剂量CT (ULD-CT) 越来越多地使用,这给准确的图像记录带来了挑战.
研究的目的:
- 评估一个深度学习的共同注册框架,用于在LAFOV系统中对PET/CT进行对齐.
- 为了评估框架的稳定性与低剂量PET和ULD-CT在不同的放射性追踪器.
- 通过使用定量指标和SUV准确度来验证框架的性能.
主要方法:
- 包括在LAFOV PET/CT系统上使用四种标记物 (Zr-trastuzumab,O-H,2O,F-MC225,F-FDG) 的63个扫描.
- 标准CT与PET (rCT) 与低计数PET (LC-rCT) 和ULD-CT与PET (rULD-CT) 与低剂量CT (rLD-CT) 的联合注册比较.
- 利用子相似性,贾卡德相似性,豪斯多夫距离和平均表面距离进行评估;评估SUV以获得PET准确性.
主要成果:
- 深度学习框架在所有追踪器中表现出强的性能,即使减少了PET数量和ULD-CT.
- 定量指标显示标准和减少剂量/计数场景之间的一致对齐准确度.
- 标准化摄入值 (SUV) 保持一致,证实了同登记方法的定量准确性.
结论:
- 深度学习的联合注册框架对于LAFOV系统中的PET/CT对齐是有效的,即使是低剂量PET和ULD-CT.
- 这种方法支持减少辐射暴露协议的可行性,而不会影响图像记录质量.
- 结果验证了该框架的通用性和稳定性,用于使用各种标记物的临床和研究应用.
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