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爱尔兰甲状腺髓癌发生率,治疗和存活率的趋势 - 一项为期25年的基于人口的研究
T J Crotty1, G P Sexton1, E F Cleere1
1Department of Otolaryngology-Head and Neck Surgery, St James's Hospital, James Street, Dublin 8, Ireland.
概括
分析了爱尔兰的骨髓甲状腺癌 (MTC) 发病率和生存趋势. 手术管理改善了结果,而化疗与MTC患者的存活率降低有关.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 癌症研究 癌症研究
背景情况:
- 甲状腺髓性癌症 (MTC) 是甲状腺C细胞的侵袭性恶性瘤.
- 与差异化甲状腺癌相比,MTC发病率和预后的趋势不那么明确.
- 本研究分析了爱尔兰人口中MTC趋势.
研究的目的:
- 分析爱尔兰MTC患者的发病率,治疗和生存情况.
- 确定影响MTC患者生存的因素.
- 为了观察MTC在25年期间的趋势.
主要方法:
- 在1994-2019年间诊断的152名MTC患者的回顾性分析.
- 来自爱尔兰国家癌症登记处的数据.
- 使用了卡普兰-梅尔生存分析和考克斯比例危险模型.
主要成果:
- 每10万人/年中MTC发病率为0.14例,平均年龄为53岁.
- 五年总生存率 (OS) 为67%,疾病特异性生存率 (DSS) 为73.2%.
- 手术改善了OS和DSS;化疗与较差的生存率有关.
结论:
- 在爱尔兰观察到MTC发病率,管理和存活率的变化趋势.
- 在晚期队列 (2008-2019) 中诊断的患者中,注意到改善整体存活率的趋势.
- 手术干预是改善MTC结果的关键因素.
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