损伤网络绘制用于中风后认知障碍
Yijun Zhou1, Yue Wang2, Jing Jing2
1Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
概括
这项研究揭示了中风和白质变化的脑损伤如何破坏神经网络,导致认知障碍. 白质变化显著介导了与中风相关的认知缺陷,突出了大脑刺激的潜在目标.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 脑卒中后认知障碍 (PSCI) 与心脏病发作和白质过强度 (WMH) 有关.
- 在PSCI基础上的网络断开机制尚未完全理解.
研究的目的:
- 在PSCI中绘制功能和结构网络断开的地图.
- 检查WMH在病变和认知状态之间的关系中的调解作用.
- 为了确定PSCI的潜在神经调节目标.
主要方法:
- 在376名急性缺血性中风患者中使用基于连接组的病变-症状映射 (CLSM).
- 从心脏病发作和WMH病变生成了断开连接的地图.
- 回归和调解模型分析了认知关系和WMH效应. 在78名脑小血管疾病患者中进行了验证.
主要成果:
- 心脏病和WMH创造了连贯的网络断开模式,主要影响了注意力和处理速度 (APS).
- 损伤影响得分预测了3个月的认知结果,比体积测量更好.
- WMH显著调解了心脏病发作和PSCI/APS缺陷之间的联系.
结论:
- 为PSCI建立一个网络层面的框架.
- 急性 (心脏病发作) 和慢性 (WMH) 血管病变发挥着不同的但协同作用的作用.
- 左側的temporo-parieto-occipital交叉點是一個潛在的神經調節目標.
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