肠道微生物群在患有慢性 Echinococcus multilocularis 感染的小鼠中调解了类似抑郁症的行为
Rou Wen1,2, Yunzhuo Xin1,3, Sijia Bao1
1School of Basic Medicine, Ningxia Medical University, Yinchuan, China.
NPJ biofilms and microbiomes
|February 5, 2026
概括
在老鼠中,慢性 Echinococcus multilocularis 感染导致了类似抑郁症的行为. 这与肠道微生物群的变化和改变的酸盐代谢有关,这表明神经免疫连接.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 寄生虫学的寄生虫学
背景情况:
- 气泡内菌 (AE) 是一种寄生性疾病,对中枢神经系统 (CNS) 的影响尚不清楚.
- 没有系统地研究AE对心理健康的长期影响.
研究的目的:
- 在患有慢性 Echinococcus multilocularis (E. multilocularis) 感染的小鼠模型中调查神经免疫-肠道微生物群相互作用.
- 探索将E. multilocularis感染与行为变化和中枢神经系统参与相关联的机制.
主要方法:
- 建立了慢性E. multilocularis感染的BALB/c小鼠模型.
- 使用行为评估,组织形态学,细胞计数珠阵列 (CBA) 和多omics (16S rRNA测序,元基因组学,代谢学).
- 进行了便微生物群移植 (FMT),以评估肠道微生物群的作用.
主要成果:
- 受感染的小鼠表现出类似抑郁症的行为,海马神经元缩,并破坏了微质平衡.
- 增加的亲炎性介质 (IL-6,MCP-1) 表示系统性免疫激活和神经炎症.
- 来自受感染的捐赠者的FMT在接受者中诱导了类似抑郁症的行为.
- 减少的乳酸菌丰度与降低的托/5-HT途径代谢物相关.
结论:
- 慢性E. multilocularis感染可能会通过肠道失调和代谢变化引起类似抑郁症的行为.
- 结果表明AE,肠道微生物群和神经精神疾病并发症之间存在联系.
- 这项研究为调查AE相关的心理健康问题和微生物向治疗提供了一个框架.
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