使用CEUS和SWE来预测侵袭性乳腺癌新辅助化疗的病理完整反应
Yingyan Wang1, Xuanli Jiang2, Yongyi Jiao1
1Department of Ultrasound, Affiliate Zhong Da Hospital of Southeast University, No. 87 Dingjiaqiao, Hunan Road, Gulou District, Nanjing, China.
Scientific reports
|February 5, 2026
概括
结合对比增强超声波 (CEUS) 和剪切波弹性图形 (SWE) 显示,在接受新辅助化疗 (NAC) 的乳腺癌患者中预测病理完整反应 (pCR) 是有前途的. 这种综合方法比单个方法提供了更高的准确性.
科学领域:
- 医疗成像医学成像
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 新辅助化疗 (NAC) 是乳腺癌的标准治疗方法.
- 准确预测病理完整反应 (pCR) 对于治疗优化至关重要.
- 目前的成像方法在预测NAC反应方面存在局限性.
研究的目的:
- 评估对比增强超声波 (CEUS) 和剪切波弹性图形 (SWE) 的联合诊断价值,用于预测接受NAC的乳腺癌患者的PCR.
- 为了比较CEUS和SWE的预测性能,单独和组合,与术后病理分析.
主要方法:
- 在60名乳腺癌患者中,在NAC前后进行了超声波 (US),CEUS和SWE检查.
- 评估了瘤大小变化 (ΔDCEUS%) 和硬度变化 (ΔEmax%).
- 使用接收器操作特征 (ROC) 曲线分析来比较成像参数的预测值.
主要成果:
- CEUS (ΔDCEUS%) 和SWE (ΔEmax%) 的变化与pCR有显著的相关性.
- ΔDCEUS%在所有分子亚型中显示了pCR和非pCR组之间的显著差异.
- 在 ΔDCEUS% 和 ΔEmax% 的组合中,与单独的 ΔDCEUS% (AUC = 0.871) 或单独的 ΔEmax% (AUC = 0.722) 相比,表现出更好的预测能力 (AUC = 0.906).
结论:
- CEUS和SWE的组合是预测NAC. 侵袭性乳腺癌患者pCR的有希望的工具.
- 这种综合成像方法可以帮助量身定制治疗策略并改善患者的治疗结果.
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