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表观遗传调节和FXR的翻译后修改:消化系统疾病的潜在机制和影响

Qian-Rui Mi¹, Cai-Qian Wu¹, Cheng-Guo Lv¹

¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, 430071, China.

Acta pharmacologica Sinica

|February 5, 2026

概括

准Farnesoid X受体 (FXR) 为消化系统疾病提供了新的治疗途径. 了解其表观遗传和翻译后修饰是开发肝脏疾病和IBD有效治疗的关键.

科学领域:

胃肠病学和肝病学
分子生物学分子生物学
药理学药理学是指药理学的学科.

背景情况:

消化系统疾病,包括肝脏疾病,肥胖,炎症性肠病 (IBD) 和肝肠癌,代表着日益增长的全球健康负担.
法尔内索伊德X受体 (FXR) 是由胆酸激活的核受体,是肝脏和小肠中的关键调节者.
FXR的失调与各种消化系统疾病的发病有关.

研究的目的:

综合审查FXR的结构和监管机制.
探索表观遗传修饰和后翻译修饰 (PTMs) 在FXR活动中的作用.
讨论针对消化系统疾病的FXR的治疗潜力.

主要方法:

文献综述综合了关于FXR的当前研究.
对影响FXR的表观遗传修饰 (例如,DNA甲基化,基因质修饰,非编码RNA调节) 的分析.
对FXR的各种后翻译修饰 (PTM) 的检查,包括酸化,乙化,SUMOylation,ubiquitination,O-glycosylation,甲基化,硫化和多ADP-ribosyl) 化.

主要成果:

FXR活动是由依赖带激活,表观遗传调节和PTMs的复杂相互作用来调节的.
改变的FXR修饰模式与消化系统病理的发展有关.
特定的PTM和表观遗传变化提供了潜在的治疗点.

结论:

对于一系列消化系统疾病来说,FXR是一个有前途的治疗标.
进一步研究FXR的监管网络,包括表观遗传和PTM,对于开发新疗法至关重要.
了解这些修改可以导致针对肝脏疾病,IBD和相关癌症的向治疗.

关键词:

在 FXR 和 FXR 之间.消化系统的疾病.表观遗传修饰表观遗传修饰后翻译修改后的修改.

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