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Updated: Feb 7, 2026

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells
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A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells

Published on: October 16, 2018

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针对患有治疗不耐药自身免疫疾病的儿科患者的抗CD19CAR T细胞

Marco Becilli1, Markus Metzler2,3, Claudia Bracaglia4

  • 1Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.

Nature medicine
|February 5, 2026
PubMed
概括

化学抗原受体 (CAR) T细胞疗法对患有严重自身免疫性疾病 (ADs) 的儿童显示出希望. 一系列病例发现CD19 CAR T细胞 (zorpocabtagene autoleucel) 导致显著的疾病改善和B细胞枯竭,并具有可控的副作用.

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