主体因素在慢性病中强烈地决定了肠道微生物组的变化,而不是功能
H Krukowski1,2, S Valkenburg3, A Vich Vila1,2
1Laboratory of Molecular Bacteriology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Nature microbiology
|February 5, 2026
概括
慢性病 (CKD) 中的微生物组变化与肠道传输时间和饮食有关,而不仅仅是功能. 目前对CKD的微生物标记缺乏一致性,这表明新的干预目标.
科学领域:
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
背景情况:
- 慢性病 (CKD) 中微生物的关联不一致.
- 了解肠道微生物组在CKD中的作用对于开发有效干预措施至关重要.
研究的目的:
- 调查肠道微生物组组成与估计的淋巴细胞过率 (eGFR) 和CKD进展之间的关联.
- 确定用于CKD及其进展的可靠微生物生物标志物.
主要方法:
- 在130名CKD患者的便量化基因组学.
- 交叉研究生物标志物比较,涉及4420个人.
- 分析与eGFR,CKD进展,肠道传输时间 (ITT) 和药物的关联.
主要成果:
- 肠道传输时间和药物解释了比EGFR更多的微生物群变异.
- 较低的eGFR与增加的p-cresol和indole生物合成以及减少的植物对动物CAZyme比率相关.
- 在腹腔透析患者中观察到微生物组失调,肠道炎症增加和显著的微生物特征.
- 对于eGFR (大肠杆菌,Alistipes sp.,Bifidobacterium adolescentis) 的共变体独立标记物在研究中显示出不良的复制性.
- 没有发现CKD进展的微生物预测因子.
结论:
- 慢性瘤中的微生物组变化受到肠道传输时间和营养因素的显著影响.
- 目前用于CKD的微生物生物标志物缺乏稳定性和一致性.
- 针对ITT和营养可能为CKD管理提供潜在的治疗策略.
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