使用BOLD信号波动绘制语言区域的非侵入性成像技术在儿科中:一篇综述
Juan S Bottan1,2, Reneé-Marie Ragguett3, Lingkai Tang4
1Division of Neurosurgery, Hospital Alemán, Buenos Aires, Argentina.
概括
像fMRI和fNIRS这样的非侵入性脑成像显示出在儿童中绘制语言的前景,为侵入性测试提供了替代方案. 需要进一步的研究来标准化这些技术用于临床使用.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 发病学 (Epileptology) 是一个专业的学科.
背景情况:
- 准确的语言区域映射对于小儿手术至关重要,以预防神经系统缺陷.
- 传统的侵入性方法 (瓦达测试,电皮层刺激) 对儿童有局限性.
- 像fMRI和fNIRS这样的非侵入性血液氧气水平依赖 (BOLD) 技术是新兴的替代方案.
研究的目的:
- 审查当前关于儿科中语言映射的非侵入性BOLD成像的知识.
- 综合基于任务和静止状态fMRI和fNIRS的证据.
- 在临床实践中评估它们的潜力和局限性.
主要方法:
- 在PubMed.com的综合文献搜索.
- 专注于fMRI和fNIRS研究用于儿科的语言映射.
- 包含具有影响力和经常被引用的出版物.
主要成果:
- 基于任务的fMRI是标准的,但受到儿童遵守的限制.
- 静态fMRI提供灵敏度但更广泛的网络.
- fNIRS是便携式和儿童友好的,但有空间分辨率的限制.
- 数据处理的标准化是需要跨模式.
结论:
- 基于BOLD的非侵入性成像是儿童手术评估的一个有希望的进步.
- 多中心研究和儿科专用工具对于标准化至关重要.
- 这些技术有可能改善手术前的规划和结果.
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