在患有无效食道运动的患者中减少了食道胃结合的收缩整体
Tingting Wu1, Boda Wu1, Junping Wang1
1Department of Gastroenterology, Peking University Shenzhen Hospital, 1120 Lianhua Road, Shenzhen, Guangdong Province, 518000, China.
概括
不有效的食道机动性 (IEM) 与较弱的食道胃节收缩积分 (EGJ-CI) 有关. 这种受损的EGJ屏障功能可能在IEM的发展中发挥作用,无论酸性反流水平如何.
科学领域:
- 胃肠病学 胃肠病学
- 食道生理学 食道生理学
- 高分辨率的测量力度计
背景情况:
- 无效食道运动 (IEM) 是一种影响食道收缩功能的疾病,在胃食道逆流症 (GERD) 和健康个体中观察到.
- IEM的根本原因尚未完全理解.
- 胃食道结合收缩积分 (EGJ-CI) 是一种用于评估胃食道结合 (EGJ) 屏障收缩完整性的新型度量.
研究的目的:
- 在IEM患者中评估食管胃结 (EGJ) 综合体的功能.
- 调查EGJ复合体在IEM病变发生中的作用.
- 为了比较患有IEM和正常食道运动的患者之间的EGJ-CI值.
主要方法:
- 157名参与者接受了高分辨率测量仪 (HRM),并使用芝加哥分类版本4.0.0进行分类.
- 34名患有IEM和34名正常运动的参与者使用倾向分数匹配进行了选择.
- 将包括EGJ-CI在内的HRM指标进行了比较,并对EGJ-CI和其他HRM参数进行了相关性分析.
主要成果:
- 与正常运动群相比,患有IEM的患者具有较低的远端收缩积分 (DCI) 和较高的逆流负担.
- 在IEM组与正常运动组相比,EGJ-CI显著降低,即使排除了GERD患者.
- 在EGJ-CI和DCI (r=0.275),以及EGJ-CI和综合放松压力 (IRP) (r=0.627) 之间发现了正相关性.
结论:
- 患有IEM的患者表现出降低的EGJ-CI,这表明EGJ屏障受损.
- 这种EGJ复杂功能障碍可能导致IEM的发病.
- 这些发现表明,EGJ-CI是理解IEM的相关指标,独立于反流负担.
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