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相关概念视频

DNA Replication02:40

DNA Replication

59.6K
DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
DNA replication...
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The DNA Replication Fork01:02

The DNA Replication Fork

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An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication...
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The DNA Replication Fork01:02

The DNA Replication Fork

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Replication in Prokaryotes02:35

Replication in Prokaryotes

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Overview
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S-Cdk Initiates DNA Replication02:38

S-Cdk Initiates DNA Replication

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The cell cycle is a series of events leading to DNA duplication followed by the division of cell content to form two daughter cells. The cell cycle progresses in four stages—the cell increases in size (gap 1 or G1-phase), duplicates its DNA (synthesis or S-phase), prepares to divide (gap 2 or G2-phase), and divides (mitosis or M-phase).
Two states at the origin of replication
In eukaryotes, the initiation of replication occurs at many sites on the chromosomes, called the origins of...
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Replication in Eukaryotes02:31

Replication in Eukaryotes

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相关实验视频

Updated: Feb 7, 2026

Visualization of DNA Replication in the Vertebrate Model System DT40 using the DNA Fiber Technique
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Visualization of DNA Replication in the Vertebrate Model System DT40 using the DNA Fiber Technique

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在DNA复制网络中持续调节的多稳定性.

Rui Zhong1, Yanjie Fu1, Shubao Jiang1

  • 1Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, PR China.

Nature communications
|February 5, 2026
PubMed
概括
此摘要是机器生成的。

这项研究引入了一种基于DNA的新框架,用于持续调节的多稳定性. 它可以精确控制分子系统,超越离散状态,进入各种可能性的范围.

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科学领域:

  • 生物化学 生物化学
  • 分子工程分子工程分子工程
  • 系统化学 系统化学

背景情况:

  • 传统的多稳定系统由于信号介导的相互作用,仅限于离散状态.
  • 在分子系统中实现稳定状态的连续光谱仍然是一个重大挑战.

研究的目的:

  • 为持续调节的多稳定性开发一个合理的框架.
  • 为了能够精确控制分子状态和功能.

主要方法:

  • 利用可逆位移反应介导的DNA聚合/模块之间的竞争.
  • 利用dNTP水解来沿着连续的组成梯度稳定状态.
  • 设计具有特定结构和功能的单链DNA.

主要成果:

  • 证明了实现持续调节的多态稳定性的框架.
  • 启用连续的,直角状态转换和度适应分子记忆.
  • 展示了生物催化和RNA转录等过程的下游控制.

结论:

  • 拟议的框架为分子系统提供了无与伦比的可调性.
  • 为化学和材料系统建立了一个多功能平台,具有可持续调节的多稳定性.
  • 开辟了先进分子编程和控制的新途径.