危地马拉成年人的表观遗传年龄和心脏代谢疾病:横截面分析
Melissa A Chapnick1, Elaine A Yu2,3, Alicia K Smith4,5
1Doctoral Program in Nutrition and Health Sciences, Laney Graduate School, Emory University, Atlanta, GA, USA.
Journal of health, population, and nutrition
|February 6, 2026
概括
表观遗传钟显示,危地马拉成年人患有糖尿病等心脏代谢疾病的生物衰老加速. 杜内丁PACE在所有研究条件中都显示出一致的关联,突出了其作为生物标志物的潜力.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 衰老研究研究 衰老研究
- 心血管健康 心血管健康
背景情况:
- 表观遗传钟是衰老的生物标志物,在患有心脏代谢疾病的个体中经常显示加速衰老.
- 大多数表观遗传时钟都是在西方人群中开发和验证的,因此需要在不同族群中进行研究.
- 这项研究研究了危地马拉成年人的心脏代谢状况与表观遗传加快年龄的关系.
研究的目的:
- 检查危地马拉成年人群中表观遗传衰老加速和心脏代谢条件 (肥胖,高血压,糖尿病,代谢综合征) 之间的关联.
- 在这个人群中评估三个不同的表观遗传钟 (DunedinPACE,PhenoAge,GrimAge) 的表现.
- 根据性别和特定的心脏代谢状况来确定关联中的潜在差异.
主要方法:
- 从INCAP营养补充试验队列中对1,095名成年人的横截面分析.
- 使用MethylationEPIC v2阵列评估的DNA甲基化.
- 使用DunedinPACE,PhenoAge和GrimAge计算的表观遗传年龄;通过线性回归分析了与心脏代谢条件的关联.
主要成果:
- 这三种表观遗传时钟都表明研究群体的生物衰老加速.
- 在女性中,PACE和PhenoAge显示了年龄加速,而在男性中,GrimAge显示了年龄加速.
- 所有的时钟都与糖尿病有关;DunedinPACE在所有研究的心脏代谢疾病中都显示出一致的关联.
结论:
- 在加速的DunedinPACE和多种心脏代谢疾病之间观察到一致的关联.
- 所有表观遗传时钟都显示出与糖尿病的关联,强调了表观遗传衰老与代谢健康之间的联系.
- 建议进行进一步的纵向研究,以确定这些关系的因果关系和方向性.
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