在MS诊断时的并发症及其与治疗持久性的关联:现实世界的临床数据
Henrik Ahvenjärvi1, Ida Lund1, Anne M Portaankorva1,2
1Research Unit of Clinical Medicine, Neurology, University of Oulu, Oulu, Finland.
Brain and behavior
|February 6, 2026
概括
伴随性疾病,特别是精神疾病,与多发性硬化症 (MS) 患者的可注射疾病修饰疗法 (DMT) 的治疗持续性降低有关. 早期发现并发症对于有效的RRMS管理至关重要.
科学领域:
- 神经学 神经学
- 临床医学 临床医学
- 流行病学 流行病学
背景情况:
- 在多发性硬化症 (MS) 诊断时,并发症很常见.
- 了解并发症对多发性硬化症治疗的影响对于患者护理至关重要.
研究的目的:
- 确定在芬兰被诊断患有多发性硬化症的患者中并发症的患病率.
- 分析并发症和临床特征之间的关联,治疗延迟,初始治疗选择,治疗持久性和疾病活性.
主要方法:
- 对421名芬兰复发性复发性多发性硬化症 (RRMS) 患者进行了横截面研究.
- 数据是从2018年至2022年期间的医院医疗记录中收集的.
主要成果:
- 超过一半 (51.8%) 的RRMS患者在诊断时至少有一种并发症,抑郁和偏头痛是最常见的.
- 患有任何并发症或精神疾病并发症的患者对中等有效率的注射DMT的持续性较低.
- 精神病的并发症与较高的初始复发率和增加的DMT停用有关.
结论:
- 伴随性疾病,特别是精神疾病,在RRMS中显著影响注射DMT的治疗持续性.
- 早期识别和治疗并发症对于优化RRMS管理和改善患者的治疗结果至关重要.
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