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Updated: Feb 7, 2026

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具有最小化非目标效应的治疗性腺因基编辑器

Yongsen Sun1,2, Nana Yan1,2, Hu Feng1,2

  • 1State Key Laboratory of Genome and Multi-omics Technologies, Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Gene Editing Technologies (Hainan), Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518120, China.

Protein & cell
|February 6, 2026
PubMed
概括

腺基编辑器 (ABE) 可以产生非目标效应. 一种经过修改的ABE8e变体,ABE8eY149V,表现出高效率,没有可检测的目标外突变,这使得它对基因疗法具有前景.

关键词:
胺基编辑器 胺基编辑器基因治疗的基因疗法的高保真变体.远离目标 - 远离目标

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