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新生儿的新陈代谢特征产于甲状腺功能高的母亲的新生儿

Jie Song¹, Peilian Huang², Meihong Zeng³

¹Department of Pediatrics, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.

Biomedical chromatography : BMC

|February 6, 2026

概括

甲状腺功能过高的母亲的甲 (PTU) 治疗改变了新生儿的血液代谢概况. 产前PTU暴露与降低的histidine和酸有关,影响关键的代谢途径.

科学领域:

内分泌学在内分泌学.
代谢学代谢学代谢学
新生儿健康新生儿健康

背景情况:

在怀孕期间甲状腺功能障碍需要治疗,通常是用propylthiouracil (PTU).
母亲的PTU治疗旨在使甲状腺激素水平正常化,但可能会影响胎儿的发育.
了解产前PTU暴露对新生儿的代谢影响至关重要.

研究的目的:

为了比较暴露于母亲PTU治疗的新生儿与健康对照者的血液代谢概况.
为了确定PTU暴露的新生儿的特定代谢变化和受影响的途径.
评估尽管母亲接受了PTU治疗,但对胎儿健康的潜在影响.

主要方法:

从31名暴露于PTU的新生儿和36名健康对照人群中采集了血液样本.
液体染色学-双重质谱法 (LC-MS/MS) 用于代谢物分析.
进行了差异代谢物分析和途径丰富分析.

主要成果:

与对照组相比,暴露于PTU的新生儿表现出明显的血液代谢概况.
在暴露于PTU的新生儿中观察到显著降低的histidine和酸水平.
受影响的途径包括氨回收和甘氨/胺代谢,这对生物合成至关重要.

结论:

在孕妇甲状腺功能障碍症期间产前接触PTU会导致新生儿特征性代谢特征的改变.
这些代谢变化表明对蛋白质和核酸生物合成的潜在影响.
建议对暴露于PTU的新生儿进行密切的生长和发育结果监测.

关键词:

甲状腺功能过强症甲状腺功能过强症代谢生物组的代谢生物组这是新生儿新生儿.怀孕怀孕怀孕怀孕怀孕甲甲甲甲甲甲甲甲甲甲甲

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