中枢杏仁体的正面腹侧髓输入调节老鼠的焦虑行为,如慢性暴露于光线
Jia-Ni Jing1, Xing Tan2, Chou Xu3
1Center of Cognition and Brain Science, Beijing Institute of Basic Medical Sciences, Beijing, China.
CNS neuroscience & therapeutics
|February 6, 2026
概括
长期暴露于光线会通过增加额头腹侧髓 (RVLM) 和其向中枢桃体 (CeA) 的投射活动来触发焦虑. 抑制这种途径可以减少类似焦虑的行为.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 生理学 生理学 生理学
背景情况:
- 环境光线暴露越来越多地与焦虑症有关.
- 额头腹侧髓 (RVLM) 调节交感外流和血压,并与焦虑相关的自主性失调有关.
- 在光引起的焦虑中,RVLM与中央桃体 (CeA) 之间的联系还不清楚.
研究的目的:
- 调查RVLM-CeA通路在由长期暴露于光线引起的焦虑类行为中的作用.
- 为了确定RVLM活动是否会在慢性光照条件下影响焦虑症状.
- 探索RVLM对与光相关的情感功能障碍的贡献.
主要方法:
- 鼠被暴露在慢性轻度光 (CL) 中4周以诱导类似焦虑的行为.
- 测量了血压和血类甲基荷胺水平.
- 在RVLM和CeA中的神经元活动使用c-fos表达进行了评估.
- 化学遗传和光遗传技术被用来操纵RVLM-CeA通路.
主要成果:
- 在RVLM和CeA中,CL暴露增加了血压和神经元活动,在RVLM中影响更大.
- 抑制RVLM神经元减少了CL诱导的焦虑类行为.
- 对RVLM→CeA通路的光遗传抑制降低了焦虑,而激活则在正常小鼠中触发了焦虑.
结论:
- 在RVLM→CeA电路中增强的刺激信号驱动慢性曝光导致类似焦虑的行为.
- 这项研究揭示了RVLM在调节光感应情感功能障碍方面的新机制.
- RVLM-CeA通路是对环境光刺激的焦虑反应的关键调节者.
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