同病性慢性鼻炎和喘:共同的风险因素和治疗影响-EAACI工作组的报告
Sanna Toppila-Salmi1,2,3, Sietze Reitsma4, Valérie Hox5
1Department of Otorhinolaryngology, University of Eastern Finland, Joensuu and Kuopio, Finland.
Allergy
|February 6, 2026
概括
慢性鼻炎 (CRS) 和喘经常共存,共享T2高的炎症. 诸如生物药物,阿司匹林无敏化和手术等治疗方法显示出希望,但需要个性化方法才能在N-ERD患者中获得最佳结果.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 慢性鼻炎 (CRS) 和喘是常见的,经常同时发生的疾病.
- 共有的T-辅助细胞2 (T2) 高炎症通路,涉及IL-4,IL-5和IL-13,将这些疾病联系起来.
- NSAID加剧的呼吸道疾病 (N-ERD) 是一种严重的表型,结合了CRS与鼻 (CRSwNP),喘和NSAID过敏症.
研究的目的:
- 探索CRS和喘并发症的共同风险因素.
- 评估这些疾病的当前和新兴治疗策略,特别是N-ERD.
- 确定研究缺口和优化患者护理的未来方向.
主要方法:
- 综述共同的风险因素,包括遗传,上皮屏障功能障碍和微生物组失调.
- 治疗策略的评估:生物药物 (杜皮卢马布,梅波利祖马布,奥马利祖马布等) ),无敏化后的阿司匹林治疗 (ATAD) 和内镜鼻手术 (ESS).
- 基于疾病表型和内型的治疗有效性和挑战的分析.
主要成果:
- 生物药物在T2高喘和CRSwNP中显示出显著的疗效和安全性.
- ATAD为N-ERD提供一种疾病修饰的选择,其中坚持是关键挑战.
- 通过ESS改善鼻和喘的结果,尽管可能需要重复手术.
结论:
- 个性化治疗方法至关重要,因为基于个体表型/内型的可变结果.
- 需要进一步的研究,包括对比试验,比较不同的疗法.
- 优化护理需要精细的治疗算法,生物标志物识别和长期结果评估.
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