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Updated: Feb 7, 2026

Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry
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注意GARP:葡萄糖皮质醇如何释放T细胞对抗黑色素瘤

Merel Roest1, Nuno Padrão1, Wilbert Zwart1

  • 1Department of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Cancer discovery
|February 6, 2026
PubMed
概括

葡萄糖皮质体受体 (GR) 激活通过降低GARP的调节来抑制瘤免疫力,GARP阻断TGFβ信号传递. 这一发现揭示了增强CD8+T细胞抗瘤活性和克服癌症免疫抵抗力的新机制.

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