全基性免疫细胞 perfusion 抑制了血管化3D的生长在体外瘤模型中,诱导了血管回归和脱,但促进了瘤细胞的入侵

Alexandra Raab1, Rasika Daware2, Marcelo A Szymanski de Toledo3

  • 1Institute For Experimental Molecular Imaging (ExMI), RWTH Aachen University Hospital, Aachen, Germany.

概括

在血管化的瘤模型中输注异构的外周血液单核细胞 (PBMC) 导致血管回归和瘤细胞死亡. 然而,它也出乎意料地促进了瘤细胞入侵和 stromal 激活,突出了癌症研究中的免疫相互作用.

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