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Updated: Feb 7, 2026

Polarization and Characterization of M1 and M2 Human Monocyte-Derived Macrophages on Implant Surfaces
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纤维细胞分泌的小型细胞外囊泡通过BMP4/BMPR2/Smad信号传递驱动巨细胞M2极化

Chenyang Zhang1, Si Chen1, Chenghui Qian1

  • 1Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Minhang, Shanghai 201102, P.R. China.

Oncology reports
|February 6, 2026
PubMed
概括

癌相关纤维细胞 (CAFs) 具有高POSTN表达,在头癌中促进免疫抑制. 阳性CAF驱动M2巨细胞的两极分化,有助于抵抗免疫检查点阻塞疗法.

关键词:
巨细胞的M2极化素+ 纤维细胞小小的细胞外囊泡.

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