旋转性血栓凝血仪的结果证实了泌尿病患者的静脉血栓栓塞风险预测
Konstantinos Douroumis1, Konstantinos Kotrotsios2, Napoleon Moulavasilis1
1First Department of Urology, National and Kapodistrian University of Athens.
概括
旋转性血栓形成显微镜可以改善泌尿外科手术患者的静脉血栓栓塞 (VTE) 风险评估. 这种新型的凝血试验在通过识别高风险个体来个性化VTE预防方面表现有前途.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 血液学 血液学 血液学
- 手术瘤学手术瘤学
背景情况:
- 静脉血栓塞栓症 (VTE) 是术后发病率和死亡率的重要原因.
- 目前的VTE风险评估依赖于模型,因为标准的凝血测试往往无法检测高凝血能力.
- 旋转性血栓形成显微镜 (ROTEM) 提供了一种新的方法来客观地评估凝血状态.
研究的目的:
- 评估传统和新型凝血试验与在接受泌尿外科手术的患者中风险的VTE之间的关联.
- 确定ROTEM是否可以客观地识别那些可以从VTE预防中受益的患者.
主要方法:
- 45名接受泌尿外科手术的患者使用欧洲泌尿病学协会 (EAU),美国泌尿病学协会 (AUA) 和Caprini风险评估模型 (RAMs) 进行了评估.
- 使用PT,纤维素,aPTT和ROTEM (外部和纤维素测定) 分析了凝血概况.
- 统计分析包括ANOVA和千平方测试.
主要成果:
- 在EAU VTE类别中,ROTEM变量没有显著差异.
- 在AUA风险组之间发现了外部ROTEM凝血时间 (CT) 的显著差异.
- 外在ROTEM凝块形成时间 (CFT) 和纤维素因子ROTEM A5和MCF指数在Caprini和AUA风险组之间分别有显著差异.
结论:
- ROTEM提供了详细的静脉静止评估,作为VTE RAMs的辅助,用于泌尿外科手术中的个性化预防.
- 需要进一步的研究来证实ROTEM在重大泌尿外科手术后识别高风险VTE患者的实用性.
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