在对白金敏感的复发性卵巢癌患者的二线化疗的生存分析
Vineet Talwar1, Atika Dogra1, Varun Goel1
1Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Rohini, Delhi, India.
The National medical journal of India
|February 6, 2026
概括
对于复发性卵巢癌 (ROC) 的二线化疗显示了有限的长期无进展生存率 (<20%在5年). 然而,帕克利塔塞尔/卡博普拉丁疗法在ROC患者中显著改善了复发后的生存率.
科学领域:
- 妇科瘤学 妇科瘤学
- 医学瘤学 医学瘤学
- 临床研究 临床研究
背景情况:
- 卵巢癌患者在复发时可能对初始化疗 (CT) 有反应.
- 在复发性卵巢癌 (ROC) 中评估二线CT疗效至关重要.
研究的目的:
- 评估接受二线CT的ROC患者的生存结果.
- 为了比较不同的二线CT疗法,包括脂质体 doxorubicin,paclitaxel/carboplatin和bevacizumab.
主要方法:
- 在2009-2017年间诊断的119名ROC患者的回顾性审查.
- 对人口统计,临床数据,治疗和生存状况的分析.
- 卡普兰-梅尔曲线和存活率分析的日志等级测试.
主要成果:
- 无进展生存期 (PFS) 的中位数为19个月;复发后生存期 (PRS) 为34个月.
- 在绝经前妇女中观察到更高的PFS (p=0.025).
- 与脂质体 doxorubicin/carboplatin (p<0.001) 相比,基于帕克利塔塞尔/碳烯的CT显著改善了PRS.
结论:
- 用二线CT治疗的ROC的五年PFS率低于20%.
- 二次复发很常见,影响了生存率.
- 基于paclitaxel/carboplatin的二线CT增强了ROC患者的PRS.
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