首次对一种用于门诊输液的新型皮下骨内血管接入装置进行人体评估
Jorge H Ulloa1, David J Sabbag2, Javier E Del Castillo2
1Clinica de Venas, Faculty of Medicine, Universidad de los Andes, Bogotá, Colombia.
The journal of vascular access
|February 6, 2026
概括
一种全新的皮肤下骨内 (IO) 装置为需要血管接入的患者提供了一种可行且安全的短期输液选择. 这种创新的设备在具有挑战性的情况下显示出长期使用的希望.
科学领域:
- 医疗器械 医疗器械
- 血管接入 血管接入
- 生物医学工程 生物医学工程
背景情况:
- 传统的骨内 (IO) 接入仅限于紧急情况和短时间 (≤48小时).
- 患有挑战性静脉通道或慢性病 (CKD) 的患者通常需要替代的血管通道解决方案.
- 保护外围和中央静脉对于在CKD患者的未来血液透析访问至关重要.
研究的目的:
- 评估一种全新的全皮下IO装置的可行性和安全性,用于血管接入.
- 在7天的植入期内评估设备的通透性,可用性和耐受性.
- 为了研究该设备对非突发性,长期血管接入的潜力.
主要方法:
- 前性,单臂,首次在人体上进行的研究.
- 十名具有挑战性静脉通道或CKD的患者接受了完全皮下IO装置,用于7天的输液.
- 通过放射学和临床评估合性;通过调查评估可用性和耐受性;在移植后30天内监测安全性.
主要成果:
- 在所有十名患者中成功植入和7天的穿透性,无需例行维护.
- 临床医生报告说,设备很容易植入,使用和扩展.
- 三名患者在初始输液期间报告过渡性疼痛;第三天后没有不适. 没有出现任何不良装置效应.
结论:
- 完全皮下IO装置是短期输液治疗的可行,可用和安全的选择.
- 它适合患有CKD或具有挑战性的静脉通道的患者.
- 需要进一步的研究来探索其长期内骨血管接入的潜力.
相关概念视频
Seedless Vascular Plants
67.1K
Seedless Vascular Plants Were the First Tall Plants on Earth
67.1K
One-Compartment Model: IV Infusion
520
Intravenous (IV) infusion is often utilized when continuous and controlled drug delivery is necessary, such as during surgery or in the treatment of chronic diseases. This method offers numerous advantages, including immediate drug action, precise control over dosage, and bypassing the first-pass metabolism.
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...
520
Two-Compartment Open Model: IV Infusion
600
A two-compartment model is a vital tool in pharmacokinetics, providing an essential understanding of drug behavior, especially for those administered via zero-order intravenous infusion. This model outlines two compartments: the central compartment, where elimination occurs, and the peripheral compartment.
The model illustrates the decrease in plasma drug concentration from the central compartment with a specific equation. It shows that under steady-state conditions, the drug's input rate...
The model illustrates the decrease in plasma drug concentration from the central compartment with a specific equation. It shows that under steady-state conditions, the drug's input rate...
600
Vascular Spasm
3.7K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
3.7K
Overview of the Vascular System
3.6K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
3.6K
Vascular Resistance
11.1K
Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
11.1K


