针对性治疗对机构分子瘤委员会发现的分子变化的影响:基于ESCAT分类的方法
K Rahmani Narj Abadi1, C Dupain1, I Guillou1
1Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France.
概括
分子瘤委员会在49%的癌症患者中发现了可操作的基因组变化. 基于欧洲医学瘤学会分子标临床可操作性量表 (ESCAT) I/II级的匹配疗法改善了无进展生存率和整体生存率.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 精准医学是一门精准的医学.
背景情况:
- 欧洲医学瘤学会分子标临床可操作性量表 (ESCAT) 提供了一个框架,用于在晚期癌症中对基因组变化 (GA) 进行分类.
- 分子瘤委员会 (MTBs) 讨论患者病例,以确定潜在的向疗法.
研究的目的:
- 评估在MTB讨论的患者的结果.
- 为了将患者的结果与ESCAT分类识别的基因组变化的相关性.
主要方法:
- 分析了1226名患有复发性/转移性癌症的患者,这些患者在2018-2022年期间在MTB讨论过.
- 数据包括人口统计,分子分析结果,MTB建议和临床结果 (ORR,PFS,OS).
- 结果与ESCAT基因组变化的分类相关.
主要成果:
- 分子分析在73%的患者中取得了成功,在49%的患者中确定了可采取行动的GA.
- 17%的患者被推匹配疗法,8%的患者接受了它们.
- 接受ESCAT I/II级GA匹配治疗的患者与III/IV级相比,PFS和OS显著更长.
结论:
- 在MTB分子查中发现了可操作的GA,导致8%的患者获得匹配疗法.
- 根据ESCAT I/II级别指导的匹配疗法显示出优异的PFS和OS结果.
相关概念视频
Molecular Models
43.8K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.8K
Molecular Orbital Theory II
27.6K
Molecular Orbital Energy Diagrams
27.6K
Molecular Orbital Theory I
47.7K
Overview of Molecular Orbital Theory
47.7K
Predicting Molecular Geometry
46.0K
VSEPR Theory for Determination of Electron Pair Geometries
46.0K
Molecular and Ionic Solids
20.2K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
20.2K
Kinetic Molecular Theory: Molecular Velocities, Temperature, and Kinetic Energy
29.9K
The kinetic molecular theory qualitatively explains the behaviors described by the various gas laws. The postulates of this theory may be applied in a more quantitative fashion to derive these individual laws.
29.9K


