儿科肠道衰竭的药理学挑战:一篇综述
Sean Coyne1, Kathleen M Gura2,3
1Department of Pharmacy, Boston Children's Hospital, Boston, MA, USA.
Intestinal Failure (New York, N.Y.)
|February 6, 2026
概括
肠胃营养是肠道衰竭 (IF) 管理的关键,但药物对于预防肝病和感染等并发症至关重要. 本综述涵盖了常见的儿科IF治疗方法以及肠道解剖学如何影响药物输送.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 临床药理学 临床药理学
- 肠道康复 肠道康复
背景情况:
- 肠衰竭 (IF) 管理主要依赖于肠外营养 (PN).
- 前列腺炎可能导致严重的并发症,包括肠道衰竭相关的肝病 (IFALD) 和中枢线相关的血液感染 (CLABSI).
- 药理干预对于管理FI和预防严重后果至关重要.
研究的目的:
- 对患有IF的儿科患者的常见药理治疗策略进行审查.
- 讨论短肠解剖学的变化如何影响IF的药物管理.
- 突出药理学支持在PN以外的IF管理中的重要性.
主要方法:
- 在儿科肠道衰竭中药理学干预的文献综述.
- 基于不同类型的短肠解剖学的药物管理考虑因素的分析.
- 对IF相关并发症的当前治疗策略的综合.
主要成果:
- 通常使用的药物针对IF相关的并发症,如细菌过度生长,胆固醇病和骨疾病.
- 特定的药物配方和施用途径受肠切除的程度和位置的影响.
- 优化药物治疗可以减轻与PN相关的风险,并改善患者的治疗结果.
结论:
- 药理干预是治疗儿科肠道衰竭中亲肠营养的必要补充.
- 了解肠道解剖学对药物吸收和新陈代谢的影响对于有效治疗至关重要.
- 包括量身定制的药物治疗在内的多学科管理是儿童肠道康复成功的关键.
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