一个随机对照的交叉试验,比较聚合物与半元素口服营养补充剂的液体和状况,在患有凝肠静脉瘤的患者中
Alison Culkin1, Beth Rye1, Jeremy Md Nightingale1
1Lennard-Jones Intestinal rehabilitation unit, St Mark's Hospital, Watford Road, Harrow, UK.
Intestinal Failure (New York, N.Y.)
|February 6, 2026
概括
在短肠患者中,半元素口服营养补充剂 (ONS) 与聚合物ONS相比,导致了较高的阴湿重和输出. 这种差异虽然很小,但随着时间的推移可能会积累起来.
科学领域:
- 胃肠病学 胃肠病学
- 临床营养学 临床营养学
- 短肠综合症管理管理 短肠综合症管理
背景情况:
- 短肠综合征需要限制液体以管理口腔/管输出.
- 口服营养补充剂 (ONS) 对于满足这些患者的营养需求至关重要.
- 关于不同类型的ONS在短肠综合征的影响的研究有限.
研究的目的:
- 为了比较半元素与聚合物ONS对骨湿重和输出的影响.
- 评估不同ONS配方在患有短肠综合征的患者中的疗效.
主要方法:
- 纳入了10名患有小肠 <200厘米的患者,其中有一名患有肠或囊.
- 患者在交叉设计中接受了Vital 1.5® (半元素) 或Ensure Plus® (聚合物) ONS.
- 在ONS给药后6小时内,收集和分析了Jejunal和尿液输出.
主要成果:
- 与聚合物ONS (Ensure Plus®) 相比,半元素ONS (Vital 1.5®) 的结果是明显更高的阴茎湿重 (P < 0.001) 和阴茎产量 (P = 0.003).
- 观察到的平均差异为湿重的0.1公斤和的13毫摩尔.
- 两种ONS类型之间在便平衡,尿液或尿液体积上没有发现显著差异.
结论:
- 在短肠患者中,半元素的ONS会导致比聚合物ONS更大的阴湿体重减轻.
- 虽然每天的差异很小,但半元素的ONS对乳头输出的累积影响值得考虑.
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