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猪的实验模型用于评估内镜切除中使用的溶液
Annita Cavalcante Farias Leoncio1, Carlos Kiyoshi Furuya1, Christiano Makoto Sakai1
1Department of Gastrointestinal Endoscopy Unit, Oswaldo Cruz German Hospital, São Paulo, Brazil.
iGIE : innovation, investigation and insights
|February 6, 2026
概括
曼尼托尔与化溶液在内镜切除中为粘膜下注射提供了有利的结果. 20%曼尼托尔与0.9%化 (Ma-Na90) 显示出更高的持续时间和泡产量,而10%曼尼托尔与0.45%化 (Ma-Na45) 显示出更高的电阻.
科学领域:
- 胃肠病学 胃肠病学
- 内镜手术 进行内镜手术
- 生物材料科学 生物材料科学
背景情况:
- 粘膜下注射对于内镜切除至关重要,为防止穿孔创造一个缓冲.
- 注射液的选择会影响泡的耐用性,程序的方便性和安全性.
- 评估不同的解决方案对于优化内镜切除技术至关重要.
研究的目的:
- 为了比较下注射溶液的耐用性,内镜师感知的质量和电阻.
- 为了确定一个最佳的解决方案,内镜下粘膜切割 (ESD) 程序.
主要方法:
- 一项双盲研究比较了蓝眼,Voluven (6%的基乙烯粉),10%的曼尼托尔/.45%的NaCl (Ma-Na45) 和20%的曼尼托尔/.9%的NaCl (Ma-Na90).
- 第一个阶段:在体内注射到猪胃中.
- 第二阶段:由两个内镜医生进行内镜切除.
- 第3阶段:电阻测量在纯溶液和活体胃组织中.
主要成果:
- 马纳90表现出最长的持续时间 (28分钟),而马纳45是最短的 (10分钟).
- 马纳45被评为令人满意;Voluven被评为不令人满意. 马纳90产生了最多的泡.
- 马纳45具有最高的电阻 (89.62 Ω溶液,391 Ω组织);马纳90具有较低的电阻 (23 Ω溶液,55.75 Ω组织). 没有发生任何穿孔.
结论:
- 选择最佳的下注射溶液需要平衡多个因素,如耐用性和电气性能.
- 曼尼托与化溶液的配合显示出整体良好结果和可访问性.
- 马纳90和马纳45具有明显的优势,建议根据程序需求量身定制使用.
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