慢性脚不稳定性中自身感知缺陷与大脑小虫的结构和功能交替有关
Xiao'ao Xue1, Yuwen Zhang1,2, Le Yu1,3
1Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Sports medicine and health science
|February 6, 2026
概括
慢性脚不稳定 (CAI) 与小脑的变化有关. 在CAI患者中,较低的灰质体积和小脑虫子中较高的活动与较差的脚亲感相关.
科学领域:
- 神经科学是一个神经科学.
- 整形外科 整形外科 整形外科
- 放射学 放射学是一门学科.
背景情况:
- 脚亲感缺陷在慢性脚不稳定 (CAI) 中很常见.
- 这些缺陷背后的中枢神经病理机制仍未得到充分研究.
- 小脑在自身感知和运动控制中的作用已经得到了很好的证实.
研究的目的:
- 为了研究CAI患者和健康对照者之间的小脑虫的结构和功能差异.
- 为了确定这些小脑区别是否与CAI的自身感知缺陷有关.
- 探索CAI中潜在的中央神经病理机制.
主要方法:
- 这是一项涉及22名CAI患者和25名健康对照者的横截面研究.
- 使用结构性和静止状态功能性MRI (fMRI) 来评估小脑虫.
- 计算了灰质体积的基于voxel的形态测量 (VBM) 和大脑活动的低频波动 (fALFF) 分数幅度.
- 相关性分析将小脑发现与脚亲感测试结果联系起来.
主要成果:
- 与对照人群相比,CAI患者的小脑体亚区域IV/V显示灰质体积 (VBM) 显著降低 (科恩d = -0.968).
- 患有CAI的患者在体IV/V中表现出明显更高的fALFF值,表明活性增加 (科恩d = 0.666).
- 在CAI患者中,自身感知得分与VBM (r = 0.622) 和fALFF (r = -0.512) 在虫中显著相关.
结论:
- 患有CAI的患者表现出灰质体积减少和小脑虫体活性增加.
- 在CAI中,自身感知缺陷的严重程度与灰质体积和活动水平有显著的关联.
- 这些发现表明,小脑变化可能在CAI病理生理学中发挥作用,并可以为未来的诊断和治疗策略提供信息.
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