通过CCL2抑制,IFN-γ保护人类的血脑屏障免受Toxoplasma gondii介导的功能障碍
Research square
|February 6, 2026
概括
毒素菌感染通过增加CCL2.2,危害了血脑屏障. 干扰素- (IFN-γ) 通过限制CCL2,保持屏障完整性来保护中枢神经系统 (CNS).
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 毒素菌感染了全球人口的很大一部分.
- 寄生虫对人类血脑屏障 (BBB) 的影响尚不清楚.
研究的目的:
- 为了调查T. gondii感染是否直接损害BBB完整性,使用人类诱导的多能干细胞衍生的脑类微血管内皮细胞 (BMEC) 模型.
- 确定T. gondii通过哪些机制影响BBB功能,并探索潜在的保护因素.
主要方法:
- 利用人类诱导的多能干细胞衍生的脑类微血管内皮细胞 (BMEC) 作为人类BBB模型.
- 评估了T. gondii感染对BMEC屏障完整性的影响.
- 测量了单细胞化疗蛋白-1 (CCL2) 的分泌和干扰素-玛 (IFN-γ) 的作用.
主要成果:
- T. gondii感染诱导了BMECs显著的CCL2分泌.
- 在感染期间,CCL2被确定为BBB功能障碍的关键调解者.
- 发现干扰素- (IFN-γ) 限制了CCL2的释放,并防止了寄生虫诱导的屏障损伤.
结论:
- 冠状病毒感染会通过CCL2分泌破坏人类的BBB.
- IFN-γ激活了对T. gondii的内在BMEC防御机制.
- 这项研究揭示了IFN-γ在T. gondii感染期间维持中枢神经系统完整性的新型保护作用.
更多相关视频
11:21Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity
Published on: March 12, 2015
11.5K
08:04Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
Published on: July 9, 2014
16.3K
相关概念视频
The Blood-brain Barrier
53.1K
Overview
53.1K
Protection of Alcohols
8.1K
This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
8.1K
Zones of Protection
808
In power systems, the entire setup is divided into protective zones to isolate faults and protect the rest of the network. These zones include generators, transformers, buses, transmission lines, distribution lines, and motors. Each zone can be visualized as a separate room in a house, with each room protected by its own circuit breaker.
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
808
Radial System Protection
445
Radial systems employ time-delay overcurrent relays to reduce load interruptions. When a fault occurs, the nearest breaker opens first, while upstream breakers remain closed due to longer delay settings. This approach ensures minimal disruption to the rest of the system.
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
445
Protecting Self-Esteem
218
Self-esteem, a central component of psychological well-being, is actively maintained through various cognitive and behavioral strategies. Individuals employ specific mechanisms to preserve a positive self-concept and mitigate threats to their self-worth, particularly in contexts involving social evaluation or personal feedback. Four primary techniques are commonly used to sustain self-esteem.Manipulating AppraisalsOne prominent strategy involves manipulating appraisals from others. Individuals...
218
Physiological Barriers
5.3K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
5.3K
