Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.7K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.7K
Genomics02:02

Genomics

40.8K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.8K
The Derivative as a Function01:26

The Derivative as a Function

117
A derivative quantifies how a function changes in response to variations in its input. It provides a localized rate of change, representing the slope of the tangent line to the function at any given point. When this process is applied systematically across the entire domain of the function, it yields a new function—the derivative function—which encodes the rate of change at every point. This concept is central to calculus and essential for understanding the behavior of dynamic...
117
Genetics of Speciation02:16

Genetics of Speciation

21.7K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.7K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

9.2K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.2K
Derivatives of the Trigonometric Functions01:26

Derivatives of the Trigonometric Functions

484
The motion of a Ferris wheel rotating at a constant speed provides an intuitive model for understanding trigonometric functions and their derivatives. As a rider moves along the circular path, the vertical height above the ground changes smoothly and periodically over time. This vertical motion can be accurately represented by a sine function, reflecting the repeating pattern of ascent and descent inherent to circular motion.Height and Rate of ChangeIf the rider’s height is modeled by a...
484

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Post-COVID-19 Rhinocerebral Mucormycosis, a Life-Threatening Event in the Background of an Immunosuppressive Condition: A Case Report.

Iranian journal of pathology·2026
Same author

Clinically aligned rationale generation for glaucoma subtype classification via a knowledge-distilled language model.

medRxiv : the preprint server for health sciences·2026
Same author

Sparse-Observation Multi-Horizon Glaucoma Progression Forecasting with Biologically Constrained Temporal Consistency: A Glaucoma Case Study.

Research square·2026
Same author

Genome-Wide Association Study for Glucocorticoid-Induced Ocular Hypertension.

Ophthalmology science·2026
Same author

Spatial Decomposition of Longitudinal RNFL Maps Reveals Distinct Modes of Glaucomatous Progression With Structure-Function and Genetic Signatures.

Investigative ophthalmology & visual science·2026
Same author

Plasma soluble triggering receptor expressed on myeloid cells 2 levels and clinical outcomes in acute decompensated heart failure: A retrospective cohort study.

The Journal of international medical research·2026

相关实验视频

Updated: Feb 7, 2026

Genome-wide Analysis using ChIP to Identify Isoform-specific Gene Targets
11:19

Genome-wide Analysis using ChIP to Identify Isoform-specific Gene Targets

Published on: July 7, 2010

15.0K

深度学习衍生的与眼相关的内类型使得全基因组的新型遗传和功能发现成为可能.

Liyin Chen, Yan Zhao, Saber Kazeminasab Hashemabad

    Research square
    |February 6, 2026
    PubMed
    概括

    机器学习使用光学连贯性断层扫描识别了初级开角青光眼 (POAG) 的新遗传联系. 这种方法发现了新的基因,提供了对POAG原因和潜在药物点的见解.

    科学领域:

    • 眼科医生 眼科 眼科
    • 遗传学 是一个遗传学.
    • 人工智能的人工智能

    背景情况:

    • 主要开角青光眼 (POAG) 是不可逆转失明的主要原因.
    • 以前的全基因组关联研究 (GWAS) 受到电子健康记录中的不精确表型的限制.
    • POAG的遗传结构在很大程度上仍然无法解释.

    研究的目的:

    • 利用机器学习 (ML) 框架与光学连贯性断层扫描 (OCT) 衍生的内分类型来识别与POAG相关的新型遗传位点.
    • 扩大对POAG遗传架构及其潜在机制的理解.
    • 为了发现POAG的潜在治疗点.

    主要方法:

    • 开发了一种疾病训练,任务转移的ML框架,以分析来自临床OCT扫描的玻璃眼相关损伤模式.
    • 应用ML衍生的OCT内类型到GWAS在英国生物库参与者跨欧洲,非洲和亚洲祖先.
    • 进行了广泛的功能分析,包括局部化,基因测试,孟德尔随机化和单细胞丰富.

    主要成果:

    • 在欧洲和跨祖先的元分析中分别确定了36个和43个全基因组显著的位置.
    • 发现了21个与POAG相关的新型位点,扩大了已知的遗传关联.
    • 汇聚了11个高信任效应基因,五个是青光眼的新奇基因,涉及Wnt介导的外流功能障碍和视网膜质细胞脆弱性.

    更多相关视频

    Genetic Manipulation in Δku80 Strains for Functional Genomic Analysis of Toxoplasma gondii
    09:52

    Genetic Manipulation in Δku80 Strains for Functional Genomic Analysis of Toxoplasma gondii

    Published on: July 12, 2013

    17.6K
    Novel Sequence Discovery by Subtractive Genomics
    09:40

    Novel Sequence Discovery by Subtractive Genomics

    Published on: January 25, 2019

    9.1K

    相关实验视频

    Last Updated: Feb 7, 2026

    Genome-wide Analysis using ChIP to Identify Isoform-specific Gene Targets
    11:19

    Genome-wide Analysis using ChIP to Identify Isoform-specific Gene Targets

    Published on: July 7, 2010

    15.0K
    Genetic Manipulation in Δku80 Strains for Functional Genomic Analysis of Toxoplasma gondii
    09:52

    Genetic Manipulation in Δku80 Strains for Functional Genomic Analysis of Toxoplasma gondii

    Published on: July 12, 2013

    17.6K
    Novel Sequence Discovery by Subtractive Genomics
    09:40

    Novel Sequence Discovery by Subtractive Genomics

    Published on: January 25, 2019

    9.1K

    结论:

    • 这种基于ML的方法成功地确定了新的POAG遗传位点和潜在的因果基因.
    • 结果提供了在细胞类型分辨率下对POAG病原体的机制性见解.
    • 这项研究提出了一个强大的,可通用的策略,用于发现疾病机制和复杂疾病的治疗点.