生物社会微生物群:性别认同,地理和粘膜微生物表型
Research square
|February 6, 2026
概括
变性女性 (TGW) 和与男性发生性关系的男性 (MSM) 有不同的直肠微生物群,受性别认同和地理因素的影响. 女性化激素治疗没有显著改变TGW的直肠微生物群.
科学领域:
- 微生物组研究的研究.
- 艾滋病毒预防科学科学
- 跨性别者健康问题
背景情况:
- 跨性别女性 (TGW) 面临着高艾滋病毒发病率和独特的荷尔蒙环境,但他们的粘膜微生物组仍未得到充分研究.
- 性别认同,女性化激素治疗 (FHT) 和地理位置对TGW粘膜微生物组成的影响在很大程度上是未知的.
- 了解这些因素对于为关键人群制定有针对性的艾滋病毒预防策略至关重要.
研究的目的:
- 调查性别认同,FHT和地理对TGW和与男性发生性关系的 cisgender男性 (MSM) 的直肠和新阴道粘膜微生物群的影响.
- 在TGW中识别与艾滋病毒风险因素相关的微生物差异.
- 探索FHT启动后直肠微生物群的潜在变化.
主要方法:
- 在美国亚特兰大和泰国曼谷进行了涉及高频女性和无艾滋病毒感染的MSM的横截面和纵向研究.
- 收集用于16S rRNA测序的直肠和新阴道粘膜拭子,以分析微生物群组成.
- 使用线性分解建模和BOUTH分析评估微生物群落,性别认同,地理位置和血清激素水平之间的关联.
主要成果:
- 结直肠微生物群的组成因性别认同和地理位置而有显著差异.
- 跨性别女性显示了雌激素代谢类型的丰富,而MSM在亚特兰大具有Prevotellaceae的丰富.
- 新阴道微生物群与直肠微生物群不同,与艾滋病毒血清转换相关的种群丰富;短期FHT没有显著改变直肠微生物群.
结论:
- 性别认同是塑造与TGW中艾滋病毒脆弱性相关的粘膜微生物表型的一个重要因素.
- 地理位置在确定粘膜的微生物组成方面也起着至关重要的作用.
- 粘膜微生物群可能会影响TGW的HIV风险,需要在预防工作中考虑这些因素.
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