在仅用化疗治疗的晚期食道状细胞癌中,PD-L1表达作为负预测生物标志物
M Sachdeva1, J J Zhao1,2, K X Zhu3
1Department of Haematology-Oncology, National University Cancer Institute, National University Hospital, Singapore.
ESMO gastrointestinal oncology
|February 6, 2026
概括
编程死亡配体1 (PD-L1) 表达在接受单独化疗的晚期食道状细胞癌 (aESCC) 患者的整体生存期负面预测. 高PD-L1表达表明这个患者群体的死亡风险更高.
科学领域:
- 在瘤学瘤学.
- 生物标志物研究 生物标志物研究
- 临床试验 临床试验
背景情况:
- 编程死亡配体1 (PD-L1) 表达是一种已知的生物标志物,用于晚期食道状细胞癌 (aESCC) 免疫治疗反应.
- 针对aESCC仅用化疗治疗的患者中PD-L1的预后作用尚不清楚.
- 这项研究调查了PD-L1作为ESCC患者接受一线化疗的预后因素的重要性.
研究的目的:
- 为了确定PD-L1表达在晚期食道状细胞癌 (aESCC) 患者的预后意义.
- 为了评估PD-L1表达与仅接受一线化疗治疗的患者的结局之间的关联.
主要方法:
- 系统搜索和提取在aESCC中评估PD-L1的III期随机试验.
- 利用图形重建算法 (包括KMS减法) 来导出PD-L1子组卡普兰-梅尔图.
- 用Cox比例危险模型对个体患者数据进行元分析,以评估整体生存期 (OS) 和无进展生存期 (PFS).
主要成果:
- 在五项试验中对1517名患者的整体生存分析中,高PD-L1表达与显著更高的死亡风险相关 (HR 1.153,P=0.025).
- 在对来自三个试验的949名患者的无进展生存分析中,高PD-L1表达表明瘤进展风险增加非显著 (HR1.076,P=0.349).
- 在这个队列中,PD-L1表达似乎是整体生存的负预测指标.
结论:
- PD-L1表达被确定为晚期食道状细胞癌 (aESCC) 患者治疗一线化疗的整体生存的负预后生物标志物.
- 这些发现表明PD-L1状态可能会影响aESCC的治疗决策和患者分层,特别是在仅使用化疗方案的背景下.
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