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口服塞马格卢提德 (Rybelsus) 开始后两周内发生深静脉血栓症:一个病例报告

Maamoun Alsermani¹, Baraa Ali Alkahmous¹, Arwa A Alhutayrashi²

¹Hematology, Prince Mohammed Bin Abdulaziz Hospital, Riyadh, SAU.

|February 6, 2026

概括

用于糖尿病和减肥的葡萄糖类-1受体激活剂 (GLP-1RAs) 可能与青少年血栓有关. 一个案例报告详细介绍了一名青少年在未经监督的情况下口服西马格卢提德后发展深静脉血栓症 (DVT).

科学领域:

内分泌学在内分泌学.
药理学药理学是指药理学的学科.
血管医学血管医学

背景情况:

类似葡萄糖-1受体激动剂 (GLP-1RAs) 广泛用于2型糖尿病和体重管理.
在青少年中,GLP-1RA的非标签使用正在增加.
新出现的数据表明GLP-1RAs与血栓塞栓事件之间存在潜在联系.

研究的目的:

在使用口服赛马格卢提德减肥的青少年中报告深静脉血栓形成病例.
要突出与未经监督的GLP-1RA在年轻成年人使用相关的潜在风险.
促使进一步调查GLP-1RAs与血栓形成之间的关联.

主要方法:

一个16岁的男性出现了急性左下肢DVT的病例报告.
在没有医疗监督的情况下开始服用口服赛马格卢提德 (每天7毫克) 减肥.
诊断工作包括双重超声波和血栓友爱查.
用抗凝剂治疗 (低分子量肝素,其次是阿皮克萨班).

主要成果:

青少年在开始服用口服赛马格卢提德的两周内出现了DVT.
双重超声波检查证实了距离表面大腿静脉和尾静脉的血栓形成.
血栓ophilia工作是负面的.
抗凝药导致显著的临床改善.

结论:

这一案例表明,口服赛马格卢提德与青少年静脉血栓形成之间存在潜在的关联.
对于非标签GLP-1RA的使用,特别是在年轻人中,仔细监督至关重要.
需要进一步的药监和机制研究来证实这种关联并阐明潜在的机制.

关键词:

它是GLP-1受体的激动剂.药物监督和药物监督鱼类的鱼.塞马格卢提德 (semaglutide) 是一种可怕的药物.静脉血栓塞栓症是一种静脉血栓塞栓.

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