在接受多西环林治疗的患者中评估急性胰腺炎:一项前性研究
Aamir Nisar Gondal1, Porus Ahmed2, Faisal Akram3
1Medicine, Royal Blackburn Teaching Hospital, East Lancashire Hospitals NHS Trust, Blackburn, GBR.
Cureus
|February 6, 2026
概括
药物诱导性胰腺炎 (DIP) 来自多西环素是不常见的,但临床上是相关的. 持续10天的多西环林治疗可能会增加急性胰腺炎的风险,需要仔细监测患者.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学 是一个学科.
- 临床医学 临床医学
背景情况:
- 药物诱导性胰腺炎 (DIP) 是一种罕见的急性胰腺炎的原因.
- 常见的抗生素多克西环素很少与DIP有关,发病率和风险因素尚不清楚.
研究的目的:
- 确定用多西环林治疗的患者急性胰腺炎的发病率和临床特征.
- 确定与多西环素诱导的急性胰腺炎相关的风险因素,包括患者人口统计和治疗持续时间.
主要方法:
- 一项长达24个月的前性观察性研究,涉及130名接受多西环林治疗的成年患者.
- 每周对患者的症状和生化标志物进行监测;使用修订的亚特兰大标准诊断急性胰腺炎.
主要成果:
- 在124名参与者中,有7名 (5.6%) 患有急性胰腺炎,平均发病时间为8.1天.
- 较长的多西环林治疗持续时间 (平均12.3天) 与风险增加有关 (p=0.03);年龄,性别和BMI没有显著关联.
- 受影响的患者出现了经典症状,胰腺酶升高,在保守管理下完全康复;没有观察到死亡率.
结论:
- 多西环素诱导的急性胰腺炎是一种不常见但显著的不良事件.
- 早期检测和药物戒断带来了有利的结果.
- 长时间的多西环林治疗 (>10天) 可能会增加风险,这需要临床警和患者监测.
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