中年和老年人中的时型和心血管疾病风险因素:观察性和门德尔随机化研究
medRxiv : the preprint server for health sciences
|February 6, 2026
概括
早晨的时间型与更好的心血管健康和饮食有关. 这项门德尔的随机化研究表明了温和的因果关系,强调了昼夜节律对心脏健康的重要性.
科学领域:
- 心血管健康 心血管健康
- 时间生物学 时间生物学
- 遗传学 是一个遗传学.
背景情况:
- 循环失调是一种新兴的心血管疾病风险因素.
- 时刻型是昼夜节律的指标,可能会影响心血管健康.
- 之前的研究表明,晚间时间型和心血管风险因素之间存在联系.
研究的目的:
- 使用孟德尔随机化 (MR) 调查时间型和心血管健康之间的因果关系.
- 评估时间型与美国心脏协会的生命必需8 (LE8) 评分之间的关联.
- 探索时间型在整体心血管健康和生活方式因素中的作用.
主要方法:
- 进行了观察性横截面和单样MR分析.
- 使用了来自317,730名英国生物库 (UKB) 参与者和13,396名护士健康研究II (NHSII) 参与者的数据.
- 时型是自报告的五级级;早晨时型的多基因风险评分作为MR仪器.
主要成果:
- 在UKB中,在观察性 (0.75分) 和MR (0.75分) 分析中,早晨的时刻型与较高的LE8得分有关.
- 在NHSII中,观察分析显示,在早晨 (1.57分) 的LE8得分更高,但MR分析在整体 (0.89分) 中并不显著,但在行为组件 (2.04分) 中显著.
- 早晨的时刻型始终与更健康的饮食相关,无论是对象还是分析.
结论:
- 在早晨的时刻型和改善心血管健康之间存在温和的因果关系.
- 饮食质量似乎是关键因素,将早晨的时间型和心血管健康联系起来.
- 为了证实这些发现,需要在不同种群中进行进一步的复制.
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