神经行为变化 恐惧泛化 在临床上 精神病的高风险
medRxiv : the preprint server for health sciences
|February 6, 2026
概括
临床高危精神病 (CHR+) 个体表现出更广泛的恐惧泛化,这表明改变的关联性学习可能是精神疾病的跨诊断风险因素,包括焦虑症状.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一种精神病学.
- 认知心理学 认知心理学
背景情况:
- 在精神疾病中观察到改变关联性学习,但其作为跨诊断风险因素的作用尚不清楚.
- 了解基本的学习过程可能会揭示不同临床状态的潜在漏洞.
研究的目的:
- 研究患有亚临床精神病理的个体的恐惧条件化和泛化,包括临床上患有精神病的高风险人群 (CHR+).
- 确定改变恐惧概括是否代表精神疾病的跨诊断风险因素.
主要方法:
- 功能磁共振成像 (fMRI) 用于在恐惧调节和概括范式期间收集大脑数据.
- 参与者 (N=72) 包括对照组和患有亚临床精神病理的人,其中23人是CHR+.
- 心理学建模分析了与恐惧概括相关的神经反应和记忆评级.
主要成果:
- 在CHR+组中,个体表现出明显更宽的恐惧概括曲线,这表明左前胰岛反应的值更高.
- 在所有参与者中,焦虑症状与更广泛的恐惧概括值相关.
- 预期的恐惧泛化模式被观察到在前侧胰岛,上额头,和记忆评级.
结论:
- 恐惧概括的具体变化,一种基本的关联记忆过程,与CHR+状态有关.
- 更广泛的恐惧泛化可能成为精神疾病的跨诊断风险因素,包括精神病和焦虑症.
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