白质微观结构调解了双极性障碍风险人群中休息活动节律不稳定和躁狂症状之间的联系
medRxiv : the preprint server for health sciences
|February 6, 2026
概括
休息活动不稳定可能会破坏青少年和年轻人的白质,增加双相情感障碍 (BD) 风险. 稳定睡眠-清醒周期可能会保护大脑结构并减少BD的脆弱性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 青春期和年轻的成年期是双相情感障碍 (BD) 发病的关键时期.
- 睡眠和休息活动节律的不稳定性与BD风险增加有关.
- 前肢白质的完整性对于情绪调节至关重要,并且可能会受到节律障碍的影响.
研究的目的:
- 调查神经对双相情感障碍脆弱性的相关关系.
- 检查睡眠/休息活动节奏不稳定性和前边边缘路径中的白质组织之间的关系.
- 确定白质完整性是否可以预测风险人群未来情绪症状.
主要方法:
- 112名 (16-24岁) 具有不同躁狂脆弱性的参与者接受了为期14天的动图和扩散核磁共振.
- 神经元导向分散和密度成像 (NODDI) 在关键路径中评估了白质组织 (导向分散指数 - ODI).
- 分析了睡眠持续时间的变化,睡眠开始的变化,循环功能指数 (CFI) 和躁狂/抑郁症症状.
主要成果:
- 较低的CFI (更大的不稳定性) 与较高的ODI (白质失调) 相关,在更高的躁狂脆弱性中,带膜束和无膜束中.
- 在6个月的随访中,更高的未切割的囊 ODI 预测了躁狂症状的增加.
- 无刺 ODI 完全调解了昼夜不稳定和躁狂症状之间的关联.
结论:
- 休息活动的不稳定性可能会破坏前边缘白质,从而增加易受伤害的个体的躁狂风险.
- 保持稳定的休息活动节奏可能是维护白质完整性的策略.
- 针对昼夜节律稳定的干预措施可能有助于减轻双相情感障碍的风险.
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