在两个潜在的队列中,心脏压力,虚弱和死亡风险
medRxiv : the preprint server for health sciences
|February 6, 2026
概括
虚弱和心脏压力 (HS) 显著增加死亡风险. 结合脆弱性和HS构成最高风险,突出需要综合评估以改善患者的治疗结果.
科学领域:
- 老年学与公共卫生
- 心脏病学和内科医学.
- 生物统计学和流行病学
背景情况:
- 虚弱是一种复杂的综合征,与衰老和增加的死亡率有关.
- 心脏压力 (HS) 也是死亡的独立风险因素.
- 脆弱性和HS对死亡率的综合影响尚不清楚.
研究的目的:
- 调查结合脆弱性和心脏压力 (HS) 与全因死亡率之间的关联.
- 为了确定患有脆弱性和HS的个体是否面临比患有其中一种或两者都不存在的个体更高的死亡风险.
主要方法:
- 使用NHANES和HRS的数据进行前性队列研究.
- 通过自我报告,生物标志物和综合指数评估的脆弱性.
- 心脏压力 (HS) 由高NT-proBNP水平来定义.
- 考克斯比例危险模型用于分析死亡风险.
主要成果:
- 患有虚弱和/或HS的参与者显示死亡风险明显增加 (HRs1.81-5.54).
- 在患有脆弱性和HS的人群中,死亡风险最高.
- 对于联合脆弱性和HS的特定HRs在队列和脆弱性指数中从3.43到5.54不等.
结论:
- 脆弱性和心脏压力 (HS) 的同时发生是常见的,并显著增加死亡风险.
- 将HS评估整合到脆弱性评估中可以增强风险分层.
- 这些发现支持针对患有脆弱性和HS的个体进行有针对性的干预.
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