首次在人体中使用低强度聚焦超声波,针对精神分裂症的条状回路:可行性,安全性和对幻觉和条状状功能连接的影响
medRxiv : the preprint server for health sciences
|February 6, 2026
概括
低强度聚焦超声波 (LIFU) 通过调节深层大脑电路,在精神分裂症患者中安全地减少听觉幻觉. 这种非侵入性技术还减少了异常的大脑连接,显示了精神病治疗的前景.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗技术 医疗技术 医学技术
背景情况:
- 听觉幻觉是精神分裂症 (SZ) 的残疾症状之一.
- 这些幻觉与深层状回路中的异常信号联系在一起,例如状核 (NAc) 和尾状头 (CH).
- 这些深层大脑结构的非侵入性调节一直是具有挑战性的.
研究的目的:
- 评估低强度聚焦超声波 (LIFU) 对SZ听觉幻觉的可行性和影响.
- 调查LIFU对深层状电路活动和连接性的影响.
主要方法:
- 一个涉及主体内的交叉可行性试验,涉及活跃的LIFU (NAc,CH) 和假控制会话.
- 休息状态fMRI和幻觉症状严重程度评估在基线和声波后.
- 声学模拟以确认目标接触.
主要成果:
- 在所有参与者中,LIFU的安全交付和耐受性都很好.
- 与基线相比,活性LIFU对NAc和CH显著降低了幻觉严重程度.
- LIFU降低了异常高的条纹-上皮层 (STC) 连接.
结论:
- 深层条纹性LIFU是一种安全和可行的神经调节技术,用于SZ.
- LIFU诱导功能连接的变化与幻觉症状的减少相关.
- 这项研究提供了LIFU作为治疗目标和精神病生物标志物的概念证明.
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