慢性前列腺炎/慢性骨盆疼痛综合征 (CP/CPPS) 中免疫功能障碍的表观遗传调节
medRxiv : the preprint server for health sciences
|February 6, 2026
概括
慢性前列腺炎/慢性盆腔疼痛综合征 (CP/CPPS) 涉及免疫失调和改变的DNA甲基化. 脱甲基化疗法可以通过恢复免疫反应和减少盆腔疼痛来治疗这种情况.
科学领域:
- 免疫学 免疫学 免疫学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 慢性前列腺炎/慢性盆腔疼痛综合征 (CP/CPPS) 是一种常见的疾病,原因不明.
- 免疫系统功能障碍越来越多地与CP/CPPS有关.
- 在CP/CPPS中免疫失调的分子机制尚不清楚.
研究的目的:
- 研究适应性免疫在CP/CPPS中的作用.
- 检查CP/CPPS患者的DNA甲基化模式.
- 探索针对表观遗传修饰的潜在治疗策略.
主要方法:
- 分析了来自CP/CPPS患者和对照者的尿样中的CD4+T细胞标记物和转录因子.
- 在外周血液单核细胞 (PBMC) 和CD4+T细胞上进行DNA甲基化分析.
- 在体外和前列腺炎动物模型中评估IL-10的产生和阿扎西提丁 (AZA) 的作用.
主要成果:
- CP/CPPS患者显示Th17/Th1偏差和减少FOXP3表达在CD4+T细胞中.
- 确定了IL10和FOXP3促进体的高甲基化和炎症基因的低甲基化.
- 在动物模型中,阿扎西提丁治疗恢复了IL-10分泌,并降低了疼痛敏感性.
结论:
- CP/CPPS与影响免疫调节和IL-10反应的表观遗传变化有关.
- 抑制DNA甲基化可以恢复免疫功能并缓解疼痛.
- 脱甲基化疗法为CP/CPPS提供了一个有前途的治疗途径.
相关概念视频
Epigenetic Regulation
33.8K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.8K
Epigenetic Regulation
3.9K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.9K
Chronic Pharyngitis
12.2K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
12.2K
Chronic Pancreatitis I: Introduction
745
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
745
Chronic Bowel Disorders: Introduction
804
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
804
Chronic Pancreatitis II: Collaborative Care
373
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
373


