主观认知轨迹,阿尔茨海默病生物标志物,以及发生轻度认知障碍
medRxiv : the preprint server for health sciences
|February 6, 2026
概括
研究伙伴报告的主观认知衰退 (SCD) 的纵向增加预测了粉胺阳性老年人的轻度认知障碍 (MCI) 的进展. 这种监测可能有助于早期识别阿尔茨海默病 (AD) 风险.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 生物标志物 生物标志物
背景情况:
- 主观认知衰退 (SCD) 在老年人中很常见,可能是轻度认知障碍 (MCI) 的前身.
- 在阿尔茨海默氏症 (AD) 连续性沿线临床进展风险较高的个体的早期识别至关重要.
- 自我或研究伙伴 (SP) 报告的SCD纵向变化的实用性对于此识别仍然不清楚.
研究的目的:
- 调查自我或SP报告的SCD的纵向变化是否有助于早期识别患有临床进展风险的个人.
- 检查SCD轨迹,AD生物标志物和MCI进展之间的关联.
- 为了确定SCD的一年变化是否预测到MCI的后续进展.
主要方法:
- 来自两个纵向观测队列 (DELCODE和ADNI) 的数据.
- 包括具有基线粉样蛋白状况,≥2个SCD评估和临床随访的认知不受损 (CU) 参与者.
- 使用日常认知问卷 (自我和SP报告) 评估SCD;使用线性混合效应和多变量Cox比例危险模型进行分析.
主要成果:
- 粉样蛋白阳性个体和进展为MCI的个体在自我和SP报告的SCD中表现出更的纵向增加.
- 在粉样蛋白阳性参与者中,只有SP报告的SCD分化的进展者与非进展者的增加.
- 一年增加的SP报告的SCD预测了粉样蛋白阳性个体后续MCI的风险增加3.24倍.
结论:
- 在SP报告的认知困难的长度增加与粉素阳性CU老年人近期进展到MCI有关.
- 基于SP的纵向监测可能支持老年人群的早期临床监测.
- 这种方法提供了一种低负担的方法来识别患有AD进展风险的个体.
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