相关实验视频
Updated: Feb 7, 2026

06:58
Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
607
评估脆弱指数完整性:来自国际网络研究的见解
medRxiv : the preprint server for health sciences
|February 6, 2026
概括
逆差积累脆弱性指数 (FI) 在不同国家显示不同的结果. 在一个环境中开发的脆弱性指数 (FIs) 可能在另一个环境中应用时由于数据和编码实践的差异而无法在外部有效.
科学领域:
- 老年学是一门学科.
- 医疗信息学 医疗信息学
- 流行病学 流行病学
背景情况:
- 缺陷积累脆弱性指数 (FI) 被广泛用于评估老龄化人口的生理储备.
- 共同数据模型 (CDM) 促进了FI的国际应用,但它们在不同医疗保健系统中的有效性是不确定的.
研究的目的:
- 为了比较基于电子健康记录 (EHR) 的两个虚弱指数 (FI) 的有效性和估计值:美国的退伍军人事务FI (VAFI) 和英国的电子FI (eFI).
- 评估FI在不同国际数据库和医疗保健环境中应用时的外部有效性.
主要方法:
- 一项国际网络研究比较了VAFI和eFI在美国和英国的五个大型EHR数据库中的估计.
- 数据包括"我们所有人"和IQVIA Pharmetrics+数据库 (美国),IMRD-THIN,IMRD-EMIS和英国BioBank数据库 (英国).
- 分析包括回顾期和FI结构的变化.
主要成果:
- 在美国和英国数据库中,在VAFI和eFI之间观察到脆弱性患病率的显著差异.
- 在美国数据库中,VAFI发现了较高的脆弱比例 (例如,在"我们所有人"中10.3%与2.5%相比).
- 在英国的数据库中,eFI发现了较高的脆弱比例 (例如,IMRD-THIN中的0.08%与<0.003%).
结论:
- 脆弱指数 (FI) 估计取决于上下文,受当地编码行为和医疗保健系统激励因素的影响.
- 金融机构的外部有效性是有限的,即使在使用共同数据模型 (CDM) 时也是如此.
- 在其原始开发环境之外应用FI时建议谨慎;建议进一步开发仪器.
更多相关视频
05:53Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
17.1K
04:00Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
Published on: July 26, 2024
1.4K
相关概念视频
Protein Networks
4.6K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.6K
Internal Energy
36.8K
The total of all possible kinds of energy present in a substance is called the internal energy (U), sometimes symbolized as E. Suppose a system with initial internal energy, Uinitial, undergoes a change in energy (transfer of work or heat), and the final internal energy of the system is Ufinal. Change in internal energy equals the difference between Ufinal and Uinitial.
36.8K
Internal Energy
7.1K
The internal energy of a thermodynamic system is the sum of the kinetic and potential energies of all the molecules or entities in the system. The kinetic energy of an individual molecule includes contributions due to its rotation and vibration, as well as its translational energy. The potential energy is associated only with the interactions between one molecule and the other molecules of the system. Neither the system's location nor its motion is of any consequence as far as the internal...
7.1K
Internal Receptors
74.7K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.7K
Network Covalent Solids
16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
International System of Units
5.1K
The International System of Units, known as the SI system, is a universally accepted measurement system recognized and used worldwide. The SI system is based on a set of three base units considered absolute, and their values do not change with location. These base units are meters, kilograms, and seconds.
Prefixes are used to define both larger and smaller quantities in the SI system. For example, milli, micro, and nano define smaller quantities, while kilo, mega, and giga are used to define...
Prefixes are used to define both larger and smaller quantities in the SI system. For example, milli, micro, and nano define smaller quantities, while kilo, mega, and giga are used to define...
5.1K