多矿物干预改善了性结肠炎患者的肠道透性:90天试验试验结果
medRxiv : the preprint server for health sciences
|February 6, 2026
概括
在性结肠炎 (UC) 患者中,Aquamin®补充剂通过降低肠道透性,改善了肠道屏障功能. 这种红色海藻的多矿物质提取物耐受性很好,可以作为UC的有益辅助疗法.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 海洋生物学 海洋生物学
背景情况:
- 以前的研究表明,Aquamin®是一种来自海洋藻类的矿物提取物,可以增强结肠屏障完整性蛋白.
- 这促使对Aquamin®对胃肠道屏障功能和性结肠炎 (UC) 透性的特定影响进行了调查.
研究的目的:
- 评估Aquamin®补充剂对轻度或缓解UC患者肠道透性的影响.
- 评估Aquamin®在这个患者群体中的安全性和耐受性.
主要方法:
- 一项涉及UC患者和健康对照者的开放性试验,他们接受了Aquamin® (800 mg/天) 90天.
- 在补充剂之前和之后使用尿道曼尼托尔分泌物测量肠道透性.
- 血清样本被分析为肝脏和功能标志物.
主要成果:
- 与对照组相比,UC患者的尿路曼尼托分泌量在基线显著增加.
- 在多个时间点内,Aquamin®补充剂减少了UC患者的尿路曼尼托尔分泌,总体显著减少29%.
- 该干预措施被很好地容忍,没有严重的不良事件,并且性酸酶水平略有降低.
结论:
- 在UC患者中,Aquamin®补充剂对肠道屏障功能和上皮质完整性产生有益影响.
- 这些发现表明,Aquamin®是UC管理的安全和有前途的辅助疗法,可能充当屏障疗法.
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