功能连接的预测因素和功能神经障碍症状变化的机制
medRxiv : the preprint server for health sciences
|February 6, 2026
概括
功能神经障碍 (FND) 症状变化与大脑网络连接有关. 改善的FND症状与功能连接的改变相关,特别是在右前侧岛屿,为疾病机制提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 功能神经障碍 (FND) 呈现出可变的临床轨迹.
- 驱动FND异质性的机制尚未得到充分理解.
研究的目的:
- 调查FND症状变化的休息状态功能连接性预测因素.
- 探索FND症状异质性背后的机制.
主要方法:
- 对32名患有FND的成年人进行自然治疗的长度研究.
- 在基线和后续评估的功能性MRI (fMRI) 和图理论指标 (中心性,整合,分离).
- 对共变量进行了调整,并与健康对照 (HCs) 进行了比较.
主要成果:
- 59.4%的患者表现出改善,症状轨迹可变.
- 较大的FND症状改善与更高的基线网络之间的集成和减少的纵向网络内部集成有关.
- 识别了右前半岛的整合作为预后标志物;在背部注意网络中增加了网络内隔离,与非核心症状改善相关.
结论:
- 大规模的网络互动是FND的潜在预后指标.
- 大脑网络的重组在机制上与FND的症状变化有关.
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