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Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
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Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
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Mitochondrial protein import is powered by two distinct energy sources: ATP hydrolysis and electrochemical potential across the inner membrane. Newly synthesized precursors are bound by cytosolic chaperones of the Hsp70 family, which guide them to the import receptors on the mitochondrial surface. Utilizing the energy of ATP hydrolysis, Hsp70 chaperones transfer these precursors to the TOM receptors on the mitochondrial outer membrane.
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疾病特定的遗传效应驱动了精神病理学与认知功能之间的关联.

Wangjingyi Liao1, Engin Keser2, Andrea Allegrini2,3

  • 1Centre for Brain and Behaviour, School of Biological and Behavioural Sciences, Queen Mary University of London, London, United Kingdom.

Biological psychiatry global open science
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概括
此摘要是机器生成的。

心理病理学的遗传风险与通过疾病特定途径的认知有关,而不是共享的跨诊断因素. 了解这些独特的遗传影响是解读心理健康和认知功能之间的复杂关系的关键.

关键词:
认知发展 认知发展认知功能 认知功能多基因分数的多基因分数心理病理学 心理病理学跨诊断的遗传风险 跨诊断的遗传风险在兄弟姐妹内部分析分析.

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科学领域:

  • 精神病学是一个精神病学.
  • 遗传学 是一个遗传学.
  • 认知神经科学 认知神经科学

背景情况:

  • 认知功能在精神病理学中至关重要,但研究不足.
  • 认知缺陷往往跨越诊断界限,使疾病特异性联系复杂化.
  • 遗传研究可以将共享 (跨诊断) 与独特的遗传效应区分开来.

研究的目的:

  • 确定心理病理学的跨诊断性和疾病特异性遗传风险因素.
  • 检查心理病理学的遗传风险如何与整个发育过程中的认知功能有关.

主要方法:

  • 使用了基因组结构方程建模.
  • 多基因分数来自一个纵向双胞胎样本 (N=7764).
  • 分析了遗传风险和认知领域之间的关联.

主要成果:

  • 精神病理学-认知关系主要是由疾病特异性的遗传风险驱动的.
  • 关联在不同疾病和认知领域有所不同.
  • 家庭内部的分析揭示了这些关联的不同途径,其中一些是强大的环境因素.

结论:

  • 特定于疾病的遗传影响对于理解精神病理与认知的联系至关重要.
  • 跨诊断遗传风险与精神病症状更相关,而不是认知功能.
  • 专注于跨诊断风险,忽视了心理病理学中认知概况的复杂性.