CAPOX引起的严重腹和肠球炎的危险因素:一项回顾性多中心研究
A Teixeira1, T Felismino2, M D Donadio2
1Clinica AMO, Salvador, Brazil.
ESMO gastrointestinal oncology
|February 6, 2026
概括
高龄和功能下降是接受capecitabine和oxaliplatin (CAPOX) 化疗的患者严重腹的关键危险因素. ангиотензин受体阻断剂 (ARB) 或ACE抑制剂并没有增加这种风险.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 之前的研究表明,capecitabine加上oxaliplatin (CAPOX) 和血管激素受体抑制剂 (ARBs) 之间存在联系,增加严重腹的风险.
- 为了验证这些发现,进行了一项较大的多中心研究,并考虑了其他潜在的风险因素.
研究的目的:
- 为了验证同时使用CAPOX和ARB/ACE抑制剂与严重腹/肠球炎之间的关联.
- 在接受CAPOX治疗的患者中,确定严重胃肠道毒性的独立风险因素.
主要方法:
- 对362名接受CAPOX治疗的结直肠癌患者进行了回顾性多中心研究.
- 主要终点:3级以上的腹和/或肠球炎.
- 用物流回归模型 (未调整和调整) 来评估风险因素.
主要成果:
- 在多变量分析中,65岁以上的年龄 (OR 2.71) 和估计的球过率 (eGFR) <60毫升/分钟 (OR 5.4) 是严重腹/肠球炎的显著独立风险因素.
- 同时使用ARB或ACE抑制剂没有发现与风险增加有显著关联.
结论:
- 年龄和功能受损是严重的CAPOX诱导腹/肠球炎的关键独立风险因素.
- 以前建议的ARBs/ACE抑制剂与CAPOX严重的胃肠道毒性之间的关联在这个更大的研究中没有得到证实.
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