一个单细胞衍生的血液转录组签名揭示了HCC的全身免疫抑制和治疗治疗后的部分逆转
Liang Zhou1,2, Ahmed Alaswad1,2, Aditi Kumthekar3
1Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany.
Frontiers in immunology
|February 6, 2026
概括
早期肝细胞癌 (HCC) 会导致血液中可以检测到的暂时免疫抑制. 移除瘤可以部分扭转这种情况,突出显示23个基因的血液特征用于HCC诊断和预后.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 文字转录学 (Transcriptomics) 是一个学科.
背景情况:
- 肝细胞癌 (HCC) 诊断和复发率影响生存率.
- 治疗疗法,如切除或切除,对于早期的HCC是有效的.
- 了解瘤负担对免疫系统的影响对于改善结果至关重要.
研究的目的:
- 研究瘤负担及其去除如何改变早期HCC的全身免疫转录组.
- 为了确定血液基的分子特征与诊断和预后潜力HCC.
- 描述HCC患者的免疫抑制机制.
主要方法:
- 在治疗前和治疗后,从HCC患者的外周血液单核细胞 (PBMC) 的单细胞RNA测序 (scRNA-seq).
- 集成scRNA-seq数据与大量的PBMC转录组和瘤和肝脏免疫细胞的公共数据集.
- 在组织样本中对已识别的免疫特征进行交叉验证.
主要成果:
- 治疗前的PBMCs显示出一种免疫抑制的转录程序,具有高的TGF-β信号传递.
- 治愈疗法部分恢复了免疫反应,但水平仍低于健康对照组.
- 来自免疫抑制单细胞子集的23个基因签名用于诊断HCC和预后生存.
结论:
- 早期的HCC会诱导一个可逆的,全身性免疫抑制转录基因组.
- 来自单细胞的23基因血液特征可以作为HCC相关免疫抑制的非侵入性生物标志物.
- 这种签名有可能用于诊断HCC和预测临床结果.
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